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Papers: 3 Oct 2020 - 9 Oct 2020
Animal Studies
PAIN TYPE:
Migraine/Headache
2020 Oct 05
Ann Neurol
Cortical spreading depression (SD) is an intense depolarization underlying migraine aura. Despite the weight of evidence linking SD to the pain phase of migraine, controversy remains over a causal role of SD in cephalgia because of the invasive nature of previous SD induction methods. To overcome this problem, we employed a novel minimally invasive optogenetic SD induction method and examined the effect SD on behavior.