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Papers of the Week
Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels.
Abstract
. Thermo transient receptor potential (thermoTRP) channels are some of the most intensely pursued therapeutic targets of the past decade. They are considered promising targets of numerous diseases including chronic pain and cancer. Modulators of these proteins, in particular TRPV1-4, TRPM8 and TRPA1, have reached clinical development, but none have been approved for clinical practice yet.