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Papers of the Week


Papers: 5 Sep 2020 - 11 Sep 2020

RESEARCH TYPE:
Psychology

PAIN TYPE:
Migraine/Headache


2020 Sep 09


Cephalalgia

Onset of action in placebo-controlled migraine attacks trials: A literature review and recommendation.

Authors

Tfelt-Hansen P, Diener H-C
Cephalalgia. 2020 Sep 09:333102420956916.
PMID: 32903063.

Abstract

Migraine patients want acute treatment to provide complete relief of the migraine attack within 30 minutes. Traditionally, "speed of onset of effect" is evaluated by estimating the time-point for first statistical separation of drug and placebo. The estimated onset of effect can be a few percent difference of patients being pain free in very large randomised, controlled trials. This difference, however, can be clinically irrelevant.