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Papers: 5 Sep 2020 - 11 Sep 2020
Animal Studies, Pharmacology/Drug Development
2020 Sep 07
Neuropsychopharmacol Rep
Although opioids have been used as treatment of neuropathic pain, opioids have abuse potential in humans. Since soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids plays a key role in the pain, sEH inhibitors would be promising new therapeutic drugs for neuropathic pain. In this study, we examined the effect of the sEH inhibitor TPPU on rewarding effects in mice using the conditioned place preference (CPP) paradigm.