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Papers: 22 Aug 2020 - 28 Aug 2020
Animal Studies, Pharmacology/Drug Development
2020 Aug 27
Br J Pharmacol
Opioids are effective painkillers. However, their risk-benefit ratio is dampened by numerous adverse effects and opioid misuse has led to a public health crisis. Safer alternatives are required but isolating the antinociceptive effect of opioids from their adverse effects is a pharmacological challenge because activation of the mu opioid receptor triggers both the antinociceptive and adverse effects of opioids.