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Papers of the Week
Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.
Abstract
Chronic stress is associated with activation of the HPA axis, elevation in pro-inflammatory cytokines, decrease in intestinal epithelial cell tight junction (TJ) proteins, and enhanced visceral pain. It is unknown whether epigenetic regulatory pathways play a role in chronic stress-induced intestinal barrier dysfunction and visceral hyperalgesia.