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Papers of the Week

Home / Publications / Pain Research Forum / Papers of the Week / Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.

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Papers: 11 Jul 2020 - 17 Jul 2020


Animal Studies


2020 Jul 14


J Neuroinflammation


http://www.ncbi.nlm.nih.gov/pubmed/32665021?dopt=Abstract


17


1

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.

Authors

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W
J Neuroinflammation. 2020 Jul 14; 17(1):211.
PMID: 32665021.

Abstract

Activated astrocytes play important roles in chronic post-surgical pain (CPSP). Recent studies have shown reactive astrocytes are classified into A1 and A2 phenotypes, but their precise roles in CPSP remain unknown. In this study, we investigated the roles of spinal cord A1 and A2 astrocytes and related mechanisms in CPSP.
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