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Papers of the Week
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes – secondary analyses of a randomised, placebo-controlled trial (the AIM study).
Abstract
Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin treatment in patients with chronic low back pain and type I or II Modic changes at the level of a previous lumbar disc herniation.