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Papers of the Week


Papers: 27 Jun 2020 - 3 Jul 2020


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 Jun 25


Ann Neurol

Anti-migraine CGRP receptor antagonists worsen cerebral ischemic outcome in mice.

Authors

Mulder IA, Li M, de Vries T, Qin T, Yanagisawa T, Sugimoto K, van den Bogaerdt A, Danser A, Wermer MJH, van den Maagdenberg AMJM, Maassen Van Den Brink A, Ferrari MD, Ayata C
Ann Neurol. 2020 Jun 25.
PMID: 32583883.

Abstract

CGRP pathway inhibitors are emerging treatments for migraine. CGRP-mediated vasodilation is, however, a critical rescue mechanism in ischemia. We, therefore, investigated whether gepants, small molecule CGRP receptor antagonists, worsen cerebral ischemia.