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Papers of the Week
Critical role of GRP receptor-expressing neurons in the spinal transmission of imiquimod-induced psoriatic itch.
Abstract
Ample evidence indicates that gastrin-releasing peptide receptor (GRPR)-expressing neurons play a critical role in the transmission of acute itch. However, the pathophysiology of spinal mechanisms underlying intractable itch such as psoriasis remains unclear. In this study, we aimed to determine whether itch-responsive GRPR neurons contribute to the spinal transmission of imiquimod (IMQ)-induced psoriatic itch.