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Papers of the Week


Papers: 20 Jun 2020 - 26 Jun 2020


Animal Studies, Pharmacology/Drug Development


2020 Jun 19


Br J Pharmacol

Spinal HSP27 participates in PDGFRβ-mediated morphine tolerance through PI3K/Akt and p38 MAPK signaling pathways.

Authors

Li Z, Peng X, Jia X, Su P, Liu D, Tu Y, Xu QQ, Gao F
Br J Pharmacol. 2020 Jun 19.
PMID: 32559815.

Abstract

The development of antinociceptive morphine tolerance is a clinically intractable problem. Previous studies clarified the pivotal roles of platelet-derived growth factor (PDGF) and its receptor PDGFRβ in morphine tolerance. Herein, we investigated the role of spinal heat shock protein 27 (HSP27) in morphine tolerance and its relationship with PDGFRβ activation.