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Papers: 20 Jun 2020 - 26 Jun 2020
Animal Studies, Pharmacology/Drug Development
2020 Jun 19
Br J Pharmacol
The development of antinociceptive morphine tolerance is a clinically intractable problem. Previous studies clarified the pivotal roles of platelet-derived growth factor (PDGF) and its receptor PDGFRβ in morphine tolerance. Herein, we investigated the role of spinal heat shock protein 27 (HSP27) in morphine tolerance and its relationship with PDGFRβ activation.