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Papers of the Week


Papers: 13 Jun 2020 - 19 Jun 2020


Animal Studies


2020 Jun 12


J Neuroinflammation


17


1

Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain.

Authors

Shaqura M, Li L, Mohamed DM, Li X, Treskatsch S, Buhrmann C, Shakibaei M, Beyer A, Mousa SA, Schäfer M
J Neuroinflammation. 2020 Jun 12; 17(1):183.
PMID: 32532285.

Abstract

Recently, mineralocorticoid receptors (MR) were identified in peripheral nociceptive neurons, and their acute antagonism was responsible for immediate and short-lasting (non-genomic) antinociceptive effects. The same neurons were shown to produce the endogenous ligand aldosterone by the enzyme aldosterone synthase.