I am a
Home I AM A Search Login

Papers of the Week


Papers: 30 May 2020 - 5 Jun 2020


Animal Studies, Pharmacology/Drug Development


2020 Jun 02


ACS Nano

Phospholipase A Inhibitor-Loaded Phospholipid Micelles Abolish Neuropathic Pain.

Authors

Kartha S, Yan L, Ita ME, Amirshaghaghi A, Luo L, Wei Y, Tsourkas A, Winkelstein BA, Cheng Z
ACS Nano. 2020 Jun 02.
PMID: 32484651.

Abstract

Treating persistent neuropathic pain remains a major clinical challenge. Current conventional treatment approaches carry a substantial risk of toxicity and provide only transient pain relief. In this work, we show that the activity and expression of the inflammatory mediator secretory phospholipase-A (sPLA) enzyme increases in the spinal cord after painful nerve root compression. We then develop phospholipid micelle-based nanoparticles that release their payload in response to sPLA activity. Using a rodent model of neuropathic pain, phospholipid micelles loaded with the sPLA inhibitor, thioetheramide-PC (TEA-PC), are administered either locally or intravenously at the time of painful injury or 1-2 days afterwards. Local micelle administration immediately after compression prevents pain for up to 7 days. Delayed intravenous administration of the micelles attenuates existing pain. These findings suggest that sPLA inhibitor-loaded micelles can be a promising anti-inflammatory nanotherapeutic for neuropathic pain treatment.