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Papers of the Week


Papers: 30 May 2020 - 5 Jun 2020


Animal Studies


2020 May 29


J Neuroinflammation


17


1

TDAG8 deficiency reduces satellite glial number and pro-inflammatory macrophage number to relieve rheumatoid arthritis disease severity and chronic pain.

Authors

Dai S-P, Hsieh W-S, Chen C-H, Lu Y-H, Huang H-S, Chang D-M, Huang S-L, Sun W-H
J Neuroinflammation. 2020 May 29; 17(1):170.
PMID: 32471455.

Abstract

The autoimmune disease rheumatoid arthritis (RA) affects approximately 1% of the global population. RA is characterized with chronic joint inflammation and often associated with chronic pain. The imbalance of pro-inflammatory and anti-inflammatory macrophages is a feature of RA progression. Glial cells affecting neuronal sensitivity at both peripheral and central levels may also be important for RA progression and associated pain. Genetic variants in the T cell death-associated gene 8 (TDAG8) locus are found to associate with spondyloarthritis. TDAG8 was also found involved in RA disease progression and associated hyperalgesia in the RA mouse model. However, its modulation in RA remains unclear.