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Papers of the Week


Papers: 30 May 2020 - 5 Jun 2020


Animal Studies


2020 May 29


Arthritis Res Ther


22


1

IL-23 in arthritic and inflammatory pain development in mice.

Authors

Lee KM-C, Zhang Z, Achuthan A, Fleetwood AJ, Smith JE, Hamilton JA, Cook AD
Arthritis Res Ther. 2020 May 29; 22(1):123.
PMID: 32471485.

Abstract

The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lymphocyte-independent, inflammatory arthritis and pain models have a similar requirement for tumour necrosis factor (TNF), granulocyte macrophage-colony stimulating factor (GM-CSF), and C-C motif ligand 17 (CCL17). Given this correlation in cytokine requirements, we explored whether IL-23 might interact with this cytokine cluster in the control of arthritic and inflammatory pain.