I am a
Home I AM A Search Login

Papers of the Week


Papers: 16 May 2020 - 22 May 2020

PAIN TYPE:
Itch


2020 May 19


Immunity


52


5

Editor's Pick

Itch: A Paradigm of Neuroimmune Crosstalk.

Authors

Wang F, Kim BS
Immunity. 2020 May 19; 52(5):753-766.
PMID: 32433948.

Abstract

Although the medical definition of itch has been in existence for 360 years, only in the last 20 years have we begun to understand the basic mechanisms that underlie this unique sensation. Therapeutics that specifically target chronic itch as a pathologic entity are currently still not available. Recent seminal advances in itch circuitry within the nervous system have intersected with discoveries in immunology in unexpected ways to rapidly inform emerging treatment strategies. The current review aims to introduce these basic concepts in itch biology and highlight how distinct immunologic pathways integrate with recently identified itch-sensory circuits in the nervous system to inform a major new paradigm of neuroimmunology and therapeutic development for chronic itch.