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Papers of the Week


Papers: 16 May 2020 - 22 May 2020


Animal Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 May 16


Cephalalgia

ATP sensitive potassium (K) channel inhibition: A promising new drug target for migraine.

Authors

Christensen SL, Munro G, Petersen S, Shabir A, Jansen-Olesen I, Kristensen DM, Olesen J
Cephalalgia. 2020 May 16:333102420925513.
PMID: 32418458.

Abstract

Recently, the adenosine triphosphate (ATP) sensitive potassium channel opener levcromakalim was shown to induce migraine attacks with a far higher incidence than any previous provoking agent such as calcitonin gene-related peptide. Here, we show efficacy of ATP sensitive potassium channel inhibitors in two validated rodent models of migraine.