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Many questions regarding the process by which self-enhancing humor style has an effect on chronic pain individuals' adjustment remain unanswered. The aim of the present study was to analyse the association of self-enhancing humor style with adjustment in a sample of individuals with chronic pain, over and above the role of catastrophizing and pain intensity. Adjustment was assessed using measures of depression, pain interference, and flourishing. We also examined the indirect association between self-enhancing humor style and adjustment via pain acceptance.