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Papers of the Week


Papers: 18 Apr 2020 - 24 Apr 2020

RESEARCH TYPE:
Psychology


Animal Studies, Pharmacology/Drug Development


2020 Apr 20


J Psychopharmacol

Treatment with slow-releasing hydrogen sulfide donors inhibits the nociceptive and depressive-like behaviours accompanying chronic neuropathic pain: Endogenous antioxidant system activation.

Abstract

Therapies to treat chronic neuropathic pain and its associated comorbidities are limited. Recent studies demonstrated that the administration of slow-releasing hydrogen sulfide (HS) donors inhibited chemotherapy-induced neuropathic pain. However, the antidepressant or anxiolytic effects of these compounds and their mechanisms of action during chronic neuropathic pain have not been evaluated.