I am a
Home I AM A Search Login

Papers of the Week


Papers: 28 Mar 2020 - 3 Apr 2020


Animal Studies, Pharmacology/Drug Development


2020


Cell Biosci


10

Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor.

Abstract

Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate whether botulinum toxin type A (BTX-A) regulates microglial M1/M2 polarization by inhibiting P2X7 expression in a rat model of NP.