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Papers of the Week


Papers: 29 Feb 2020 - 6 Mar 2020

RESEARCH TYPE:
Psychology


Animal Studies, Pharmacology/Drug Development


2020 Mar 03


Psychopharmacology (Berl)

Ketamine relieves depression-like behaviors induced by chronic postsurgical pain in rats through anti-inflammatory, anti-oxidant effects and regulating BDNF expression.

Authors

Abstract

Clinically, chronic postsurgical pain (CPSP) is very common. Many CPSP patients may experience depression. Thus far, little is known about the mechanism of the comorbidity of CPSP and depression. Ketamine has been confirmed to possess analgesic and rapid antidepressant effects, but it is unclear whether ketamine can relieve the comorbidity of CPSP and depression.