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Papers: 15 Feb 2020 - 21 Feb 2020
Animal Studies, Pharmacology/Drug Development
2020 Feb 14
Neurogastroenterol Motil
Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via corticotropin-releasing factor (CRF) and proinflammatory cytokines, which is considered to be a rat irritable bowel syndrome (IBS) model. As losartan is known to inhibit proinflammatory cytokine release, we hypothesized that it improves these visceral changes.