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Papers of the Week


Papers: 15 Feb 2020 - 21 Feb 2020


Human Studies

PAIN TYPE:
Migraine/Headache


2020 Feb 14


Cephalalgia

Mitochondrial genome-wide association study of migraine – the HUNT Study.

Authors

Børte S, Zwart J-A, Skogholt A H, Gabrielsen M E, Thomas LF, Fritsche LG, Surakka I, Nielsen JB, Zhou W, Wolford BN, Vigeland MD, Hagen K, Kristoffersen E S, Nyholt DR, Chasman DI, Brumpton BM, Willer CJ, Winsvold BS
Cephalalgia. 2020 Feb 14:333102420906835.
PMID: 32056457.

Abstract

Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial genome-wide association study of migraine, examining both single variants and mitochondrial haplogroups.