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Papers of the Week


Papers: 8 Feb 2020 - 14 Feb 2020


Human Studies


2020 07


Arthritis Rheumatol


72


7

Aberrant salience? Brain hyperactivation in response to pain onset and offset in fibromyalgia.

Authors

Hubbard CS, Lazaridou A, Cahalan CM, Kim J, Edwards RR, Napadow V, Loggia ML
Arthritis Rheumatol. 2020 07; 72(7):1203-1213.
PMID: 32017421.

Abstract

While much brain research on fibromyalgia (FM) focuses on the study of hyper-responsiveness to painful stimuli, some studies suggest that the increased pain-related brain activity often reported in FM studies may be in part explained by stronger responses to salient aspects of the stimulation rather than, or in addition to, its painfulness. We thus hypothesized that FM patients would demonstrate elevated brain responses to both pain onset and offset, two salient sensory events of opposing valences.