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Papers of the Week


Papers: 8 Feb 2020 - 14 Feb 2020


Animal Studies

PAIN TYPE:
Migraine/Headache


2020 Feb 07


J Headache Pain


21


1

The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine.

Authors

Warfvinge K, Krause D, Edvinsson L
J Headache Pain. 2020 Feb 07; 21(1):10.
PMID: 32028899.

Abstract

Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology. In order to better understand possible central actions of OT in migraine/headache pathogenesis, we mapped the distribution of OT and OTR in nerve cells and fibers in rat brain with a focus on areas related to migraine attacks and/or shown previously to contain calcitonin gene related peptide (CGRP), another neuropeptide involved in migraine.