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Papers: 25 Jan 2020 - 31 Jan 2020
Animal Studies, Pharmacology/Drug Development
PAIN TYPE:
Migraine/Headache
2020 06
Br J Pharmacol
177
11
There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 is expressed in the trigeminal ganglion and its response is potentiated by nitric oxide that can trigger migraine attacks in patients, and thus we sought to explore the potential therapeutic effect of ASIC3 blockade in migraine.