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Papers of the Week
Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway.
Abstract
The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions on descending projection neurons are unclear.