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Papers: 18 Jan 2020 - 24 Jan 2020
Human Studies, Pharmacology/Drug Development
PAIN TYPE:
Migraine/Headache
2020 04
Headache
60
4
Previous attempts to develop a pragmatic human model for testing new anti-migraine drugs, have failed. Calcitonin gene-related peptide (CGRP) induces a mild headache in healthy volunteers and migraine-like headache in migraine patients. The induced headache must respond to already established migraine treatment for validation. Thus, the objective of the study was to test the effect of sumatriptan against CGRP-induced symptoms in an attempt to validate CGRP-induced headache as a model for drug testing.