I am a
Home I AM A Search Login

Papers of the Week


Papers: 11 Jan 2020 - 17 Jan 2020


Human Studies

PAIN TYPE:
Itch


2020 05


Clin Exp Allergy


50


5

Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis.

Authors

Guseva D, Rüdrich U, Kotnik N, Gehring M, Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs BF, Ponimaskin E, Raap U
Clin Exp Allergy. 2020 05; 50(5):577-584.
PMID: 31925827.

Abstract

Pruritus is a major symptom of atopic dermatitis (AD) and is transmitted by a subpopulation of non-myelinated C-type free nerve endings in the epidermis and upper dermis. Stimulation of these nerve terminals is affected by histamine, neurotrophins and physical factors. Eosinophils of patients with AD are a source of neurotrophins, including brain-derived neurotrophic factor (BDNF), levels of which correlate with disease severity.