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Papers: 11 Jan 2020 - 17 Jan 2020
Human Studies
PAIN TYPE:
Itch
2020 05
Clin Exp Allergy
50
5
Pruritus is a major symptom of atopic dermatitis (AD) and is transmitted by a subpopulation of non-myelinated C-type free nerve endings in the epidermis and upper dermis. Stimulation of these nerve terminals is affected by histamine, neurotrophins and physical factors. Eosinophils of patients with AD are a source of neurotrophins, including brain-derived neurotrophic factor (BDNF), levels of which correlate with disease severity.