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Papers of the Week


Papers: 30 Nov 2019 - 6 Dec 2019


Animal Studies

PAIN TYPE:
Itch


2020 Jan


J Allergy Clin Immunol


145


1

Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor.

Authors

Koga K, Yamagata R, Kohno K, Yamane T, Shiratori-Hayashi M, Kohro Y, Tozaki-Saitoh H, Tsuda M
J Allergy Clin Immunol. 2020 Jan; 145(1):183-191.e10.
PMID: 31787267.

Abstract

Chronic itch is a highly debilitating symptom among patients with inflammatory skin diseases. Recent studies have revealed that gastrin-releasing peptide (GRP) and its receptor (gastrin-releasing peptide receptor [GRPR]) in the spinal dorsal horn (SDH) play a central role in itch transmission.