Browse by Audience
Skip to content
Papers of the Week
Extracranial activation of ATP-sensitive potassium channels induces vasodilation without nociceptive effects.
Abstract
Levcromakalim opens ATP-sensitive potassium channels (K channel) and induces head pain in healthy volunteers and migraine headache in migraine patients, but no pain in other parts of the body. K channels are expressed in C- and Aδ-fibers, and these channels might directly activate nociceptors and thereby evoke pain in humans.