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Papers of the Week


Papers: 26 Oct 2019 - 1 Nov 2019


Animal Studies, Pharmacology/Drug Development


2020 Mar


Br J Pharmacol


177


5

Editor's Pick

Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve-injured mice.

Authors

Martínez-Navarro M, Cabañero D, Wawrzczak-Bargiela A, Robe A, Gavériaux-Ruff C, Kieffer BL, Przewlocki R, Baños JE, Maldonado R
Br J Pharmacol. 2020 Mar; 177(5):1187-1205.
PMID: 31655493.

Abstract

Mu and delta opioid receptors (MOP, DOP) limit pain perception in physiological conditions, but their relative contribution to the manifestations of pathological pain is not completely understood. Here we used a genetic approach to investigate the opioid mechanisms modulating neuropathic pain and its comorbid manifestations.