I am a
Home I AM A Search Login

Papers of the Week


Papers: 19 Oct 2019 - 25 Oct 2019


Animal Studies

PAIN TYPE:
Migraine/Headache


2020 Mar


Cephalalgia


40


3

PD-L1 and PD-1 expressed in trigeminal ganglia may inhibit pain in an acute migraine model.

Authors

Shi S, Han Y, Wang D, Guo P, Wang J, Ren T, Wang W
Cephalalgia. 2020 Mar; 40(3):288-298.
PMID: 31640402.

Abstract

Neurogenic inflammation, mediated by the activation of primary neurons, is thought to be an important factor in migraine pathophysiology. Programmed cell death ligand-1 (PD-L1) can suppress the immune response through the Programmed cell death-1 receptor. However, the role of PD-L1/PD-1 in migraine remains unclear. In this study we evaluated the expression and role of PD-L1/PD-1 in the trigeminal ganglia in an animal model of acute migraine.