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Papers of the Week


Papers: 21 Sep 2019 - 27 Sep 2019


Human Studies


2019


J Pain Res


12

A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial.

Authors

Wahl AM, Bidstrup D, Smidt-Nielsen IG, Werner MU, Hyldegaard O, Rotbøll-Nielsen P
J Pain Res. 2019; 12:2337-2348.
PMID: 31534358.

Abstract

Animal studies have demonstrated anti-inflammatory, and anti-nociceptive properties of hyperbaric oxygen therapy (HBOT). However, physiological data are scarce in humans. In a recent experimental study, the authors used the burn injury (BI) model observing a decrease in secondary hyperalgesia areas (SHA) in the HBOT-group compared to a control-group. Surprisingly, a long-lasting neuroplasticity effect mitigating the BI-induced SHA-response was seen in the HBOT-preconditioned group. The objective of the present study, therefore, was to confirm our previous findings using an examiner-blinded, block-randomized, controlled, crossover study design.