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Papers of the Week
Monosodium iodoacetate-induced monoarthritis develops differently in knee versus ankle joint in rats.
Abstract
Disability and movement-related pain are major symptoms of joint disease, motivating the development of methods to quantify motor behaviour in rodent joint pain models. We compared effects on behaviour, assessed the levels of biochemical mediators and made a detailed histopathological evaluation after induction of rat monoiodoacetate (MIA) monoarthritis into the ankle or knee joint.