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Papers of the Week
Anxiolytic effects of the novel αδ ligand mirogabalin in a rat model of chronic constriction injury, an experimental model of neuropathic pain.
Abstract
Psychiatric disorders such as anxiety and depression are frequently observed in neuropathic pain patients, and negatively impact their quality of life. Mirogabalin is a novel ligand for the αδ subunit of voltage-gated calcium channels and has unique binding characteristics to αδ subunits and potent and long-lasting analgesic effects in neuropathic pain models.