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Papers of the Week
Low- versus high-dose intraoperative opioids: a systematic review with meta-analyses and trial sequential analyses.
Abstract
Opioid-induced hyperalgesia is a state of nociceptive sensitization secondary to opioid administration. The objective of this meta-analysis was to test the hypothesis that high-dose intraoperative opioids contribute to increased postoperative pain and hyperalgesia when compared with a low-dose regimen in patients under general anaesthesia.