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Papers of the Week


Papers: 17 Aug 2019 - 23 Aug 2019


Animal Studies

PAIN TYPE:
Itch


2019 Dec


J Allergy Clin Immunol


144


6

Keratin defects trigger the itch-inducing cytokine thymic stromal lymphopoietin via Areg-Egfr signaling.

Authors

Scheffschick A, Kiritsi D, Magin TM
J Allergy Clin Immunol. 2019 Dec; 144(6):1719-1722.e3.
PMID: 31425777.

Abstract

Loss of the keratin cytoskeleton results in upregulation of the pro-inflammatory cytokine Tslp via autocrine Areg-Egfr-Erk1/2 signaling. The Areg-Egfr axis represents a therapeutical target to moderate Tslp, inflammation and itch in EBS.