I am a
Home I AM A Search Login

Papers of the Week


Papers: 20 Jul 2019 - 26 Jul 2019


Animal Studies


2019 Jul 01


J Neurogastroenterol Motil


25


3

Vagal Transient Receptor Potential Ankyrin 1 Mediates Stress-exacerbated Visceral Mechanonociception After Antral Cold Exposure.

Authors

Chen X, Luo Q, Yan X, Li W, Chen S
J Neurogastroenterol Motil. 2019 Jul 01; 25(3):442-460.
PMID: 31327223.

Abstract

Abdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominant irritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We investigated the role of vagal transient receptor potential ankyrin 1 (TRPA1, a cold-sensing ion channel) in cold-aggravated visceral mechanonociception in a stress-induced IBS animal model.