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Papers of the Week


Papers: 20 Jul 2019 - 26 Jul 2019


Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019 Sep


Headache


59


8

CGRP and Brain Functioning: Cautions for Migraine Treatment.

Authors

Borkum JM
Headache. 2019 Sep; 59(8):1339-1357.
PMID: 31328279.

Abstract

Calcitonin gene-related peptide has emerged as a therapeutic target in migraine. Monoclonal antibodies and small molecule receptor antagonists (gepants) directed against CGRP have been approved or are in Phase II or III clinical trials. For monitoring the long-term safety of these drugs, it is helpful to consider the role of CGRP in brain functioning.