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Papers of the Week


Papers: 13 Jul 2019 - 19 Jul 2019


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2020 Jan


Cephalalgia


40


1

PACAP27 induces migraine-like attacks in migraine patients.

Authors

Ghanizada H, Al-Karagholi M A-M, Arngrim N, Olesen J, Ashina M
Cephalalgia. 2020 Jan; 40(1):57-67.
PMID: 31299857.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is found in two functional isoforms, namely PACAP38 and PACAP27. The migraine-inducing properties of PACAP38 are well studied. However, it is not known whether the lesser-known and under-studied protein isoform, PACAP27, can also induce migraine attacks. Here, we studied the effect of human PACAP27 infusion on induction of migraine in a provocation model.