I am a
Home I AM A Search Login

Papers of the Week


Papers: 6 Jul 2019 - 12 Jul 2019


Human Studies, Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019 Dec


Cephalalgia


39


14

Characterisation of vasodilatory responses in the presence of the CGRP receptor antibody erenumab in human isolated arteries.

Authors

Rubio-Beltrán E, Labastida-Ramírez A, Haanes KA, van den Bogaerdt A, Bogers A J, Dirven C, Danser A J, Xu C, Snellman J, Maassen Van Den Brink A
Cephalalgia. 2019 Dec; 39(14):1735-1744.
PMID: 31284729.

Abstract

Migraine is associated with activation of the trigeminovascular system, release of calcitonin gene-related peptide (CGRP) and dilation of dural arteries. Novel treatments target calcitonin gene-related peptide or its receptor, which are present in all vascular beds, raising cardiovascular concerns. Erenumab is a human CGRP-receptor antibody approved for the prophylactic treatment of migraine.