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Papers of the Week


Papers: 15 Jun 2019 - 21 Jun 2019


Animal Studies, Pharmacology/Drug Development


2019 Sep


Br J Pharmacol


176


17

Opioid-Sparing Effects of Cannabinoids on Morphine Analgesia: Participation of CB1 and CB2 Receptors.

Authors

Chen X, Cowan A, Inan S, Geller EB, Meissler JJ, Rawls SM, Tallarida RJ, Tallarida CS, Watson MN, Adler MW, Eisenstein TK
Br J Pharmacol. 2019 Sep; 176(17):3378-3389.
PMID: 31218677.

Abstract

Much of the opioid epidemic arose from abuse of prescription opioid drugs. This study sought to determine if the combination of a cannabinoid with an opioid could produce additive or synergistic effects on pain, allowing reduction in the opioid dose needed for maximal analgesia.