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Papers of the Week


Papers: 8 Jun 2019 - 14 Jun 2019


Animal Studies, Pharmacology/Drug Development


2019 Sep


Osteoarthritis Cartilage


27


9

A Dual Amylin and Calcitonin Receptor Agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model.

Authors

Katri A, Dąbrowska A, Löfvall H, Karsdal MA, Andreassen KV, Thudium CS, Henriksen K
Osteoarthritis Cartilage. 2019 Sep; 27(9):1339-1346.
PMID: 31176015.

Abstract

Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for therapies that can simultaneously alter disease progression and provide pain relief. KBP is a dual amylin- and calcitonin-receptor agonist with antiresorptive and chondroprotective properties. In this study we investigated the effect of KBP in a rat model of osteoarthritis.