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Papers of the Week


Papers: 8 Jun 2019 - 14 Jun 2019


Human Studies


2019 Aug


Ann Neurol


86


2

A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.

Authors

Khoury S, Piltonen MH, Ton A-T, Cole T, Samoshkin A, Smith SB, Belfer I, Slade GD, Fillingim RB, Greenspan JD, Ohrbach R, Maixner W, Neely GG, Serohijos AWR, Diatchenko L
Ann Neurol. 2019 Aug; 86(2):168-180.
PMID: 31177555.

Abstract

Heightened somatic symptoms are reported by a wide range of patients with chronic pain and have been associated with emotional distress and physical dysfunction. Despite their clinical significance, molecular mechanisms leading to their manifestation are not understood.