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Papers of the Week


Papers: 1 Jun 2019 - 7 Jun 2019


Human Studies, Pharmacology/Drug Development


2019 Oct


Eur J Pain


23


9

Cornea nerve fiber state determines analgesic response to tapentadol in fibromyalgia patients without effective endogenous pain modulation.

Authors

Abstract

Tapentadol is a centrally acting analgesic with μ-agonistic activity combined with noradrenaline reuptake inhibition. Its mechanism of action relies on improvement of descending pain inhibition. In the current study, tapentadol's ability to enhance conditioned pain modulation (CPM, an experimental measure of descending pain inhibition) was evaluated in fibromyalgia patients with absent or reduced CPM responses.