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Papers of the Week


Papers: 18 May 2019 - 24 May 2019


Animal Studies


2019 Aug


Neurogastroenterol Motil


31


8

Down-regulation of HTR1A-modulated ACC activation contributes to stress-induced visceral hyperalgesia in rats.

Authors

Yi L, Sun H, Zhang H, Chen Y, Zhou L, Xuan L, Zhan T, Jiang Y, Xu S
Neurogastroenterol Motil. 2019 Aug; 31(8):1-13.
PMID: 31121088.

Abstract

Long-term stress was suggested to cause visceral hypersensitivity and promote functional gastrointestinal disorders (FGIDs). Some brain regions such as the anterior cingulate cortex (ACC) may play an important role for generating visceral hypersensitivity; however, its molecular mechanisms are not clear. This study aimed to explore the role of 5-HT1A receptors (HTR1As) in activating ACC and corresponding mechanism, in stress-induced visceral hyperalgesia rats.