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Papers of the Week


Papers: 18 May 2019 - 24 May 2019


Human Studies, Pharmacology/Drug Development


2019 Jul


Can J Anaesth


66


7

Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial.

Authors

Moulin DE, Morley-Forster PK, Pirani Z, Rohfritsch C, Stitt L
Can J Anaesth. 2019 Jul; 66(7):820-827.
PMID: 31098961.

Abstract

Neuropathic pain, resulting from injury to the peripheral or central nervous system, is due to upregulation of aberrant sodium channels with neuronal hyperexcitability. Lidocaine blocks these channels and several studies show that intravenous (IV) lidocaine infusion provides significant relief in patients with chronic peripheral neuropathic pain in the short term (for up to six hours). Our objective was to determine if IV lidocaine provides significant pain relief and overall improvement in quality of life in the longer term (for up to four weeks).