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Papers of the Week
Sensitized brain response to acute pain in patients using prescription opiates for chronic pain: A pilot study.
Abstract
Chronic opiate use leads to a sensitized behavioral response to acute pain, which in turn, leads to escalating doses of opiates. This study was designed to test the hypothesis that chronic opiate usage is also associated with a sensitized neurobiological response to acute pain in individuals that have used prescription opiates for 6 or more months.